Foles, starting for the Jaguars for the first time after earning Super Bowl MVP honors with the Philadelphia Eagles earlier in his career, was hurt on a 35-yard touchdown pass to DJ Chark with 5:23 remaining in the first quarter.
Foles was 5-of-8 passing for 75 yards before departing.
Washington State rookie Gardner Minshew II replaced Foles.
Also, Kansas City wide receiver Tyreek Hill was carted off the field in the first quarter, and the Chiefs announced he was questionable to return with a shoulder injury.
Hill, who had two catches for 16 yards, was injured on the second reception after being tackled by Jacksonville cornerback Jalen Ramsey.
—Field Level Media