Saddier, 25, is yet to drop a shot after 36 holes at Glendower Golf Club and finished birdie-eagle-birdie in to shoot into the joint-lead of the second oldest Open championship in the world.
Paisley (65) caught a hot streak on the back nine as well, carding six birdies. His only blemish a dropped shot on the par-five 13th when he found water off the tee.
Both Saddier and Paisley are seeking their first wins on the European Tour and hold a four-shot lead over South African Jacques Kruyswijk (67), who is alone in third on nine under-par.
Home favorite Branden Grace and American Chase Koepka, the overnight joint leaders, both shot 71s to slip to five shots off the pace, along with two-time US Open champion Retief Goosen (67).
Reporting By Nick Said; Editing by Christian Radnedge